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Author Topic: FDA Alert for Zonisamide (Zonegram and generics)  (Read 9333 times)
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gel61820
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« on: February 23, 2009, 02:31:27 PM »

[span style=\'color:green\']FDA ALERT [February 23, 2009]: Following a review of updated clinical data,  the FDA has determined that treatment with zonisamide can cause metabolic acidosis in some patients.  Zonisamide is indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.

Metabolic acidosis is a disturbance in the body's acid-base balance that results in excessive acidity of the blood.  Metabolic acidosis is diagnosed by laboratory tests measuring the serum bicarbonate level in the blood to determine the presence and severity of metabolic acidosis.  

Metabolic acidosis can result in hyperventilation, and non-specific symptoms such as fatigue and anorexia, or more severe symptoms including cardiac arrhythmias or stupor.  Chronic metabolic acidosis can have adverse effects on the kidneys and on bones, and can retard growth in children.  Patients with predisposing conditions or therapies, including renal disease, severe respiratory disorders, diarrhea, surgery, ketogenic diet, or certain other drugs may be at greater risk for developing metabolic acidosis following treatment with zonisamide.  The risk of zonisamide-induced metabolic acidosis appears to be more frequent and severe in younger patients.    

The FDA recommends that healthcare professionals measure serum bicarbonate before starting treatment and periodically during treatment with zonisamide, even in the absence of symptoms.  If metabolic acidosis develops and persists, consideration should be given to reducing the dose or discontinuing zonisamide (using dose tapering), and modifying the patient
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« Reply #1 on: February 23, 2009, 07:05:14 PM »

:D HI Gel!

Thanks for the info.  Good information to know!

B)
« Last Edit: February 23, 2009, 07:05:42 PM by Dispatch » Logged

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gel61820
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« Reply #2 on: February 25, 2009, 03:14:40 AM »

:Welcome:

 :bigarmhug:  
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"Do not go where the path may lead, go instead where there is no path and leave a trail." Ralph Waldo Emerson

VNS implanted July 2007 for Epilepsy.  Activated August 2007.  No success, so VNS was turned off in August 2008 and COMPLETELY removed (including coils) on Nov 25, 2008.
tracymcclure41
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« Reply #3 on: December 27, 2010, 05:10:41 PM »

That is just great.  I have been taking this medicine for around 9 years now.  Just what I needed to hear.

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« Reply #4 on: January 18, 2011, 12:55:00 AM »

 Grin HI Tracy!

How are you?  Hoping all is well!

Take care!
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